Objective. Identify preferred neurofilament assays, and clinically validate serum NfL and pNfH as prognostic and potential pharmacodynamic biomarkers relevant to ALS therapy development. Methods. P
Genetic polymorphisms in genes of the inflammatory pathways may increase the susceptibility to develop exacerbated neuroinflammatory reactions, as well as serve as a trigger for the apoptotic processe
IntroductionVascular dementia (VaD) is one of the most common causes of dementia among the elderly. Despite this, the molecular basis of VaD remains poorly characterized when compared to other age-rel
In amyotrophic lateral sclerosis, there is a need for biomarkers to distinguish patients from controls, to follow disease progression and to provide information about the pathogenesis of disease. In a
