Dendritic cells (DCs) play an important role in innate and adaptive immunity. DCs could sense environment pathogens and tumors, presenting those antigens to T cells. PTBP1, an RNA-binding protein, the
Purpose: We have previously established an in vitro murine model that recapitulates the transformed phenotype of primary Tet2-/- mast cells expressing the Kit kinase domain mutant allele, D816V, that
Transcriptional regulatory changes have been shown to contribute to phenotypic differences between species, but many questions remain about how gene expression evolves. Here we report the first compa
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by diverse clinical symptoms. Most patients suffer from varied disease relapse-remission cycles under current
Using RNA-seq we identified the gene expression changes in MCT1-deficient B cells. Overall design: RNA seq was performed in B cells from Mb1Cre and Mct1f/fMb1Cre mice treated with LPS and IL-4 for 3 d
