Hedgehog ligand biogenesis

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

本事件系通过计算方法从另一物种中已验证的事件推断而来。该推断基于PANTHER的同源性映射。简言之，对于所有涉及物理实体（包括输入、输出和催化剂）均具有映射同源物/同源序列的反应（对于复合物而言，至少75%的组成成分需具备映射），将其推断至另一物种。此外，对于此类事件，还进行了高级别事件的推断，以便于更便捷的导航。<p>有关Reactome中事件推断的更多细节和注意事项，请参阅<a href='/electronic_inference_compara.html' target = 'NEW'>此处</a>。关于PANTHER的详细信息，请参阅<a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>。

搜集汇总

背景与挑战

背景概述

该数据集描述了哺乳动物Hedgehog配体（SHH、IHH、DHH）的生物合成过程，包括前体蛋白的自切割、胆固醇和棕榈酸修饰、细胞表面聚集以及通过多种机制（如DISP2/SCUBE2介导、多聚体形成或外泌体释放）实现长距离扩散。数据集基于从人类推断到犬物种，属于Hedgehog信号通路的一部分，用于研究发育和疾病中的配体生成与调控。