Investigate the underlying mechanisms by which Evo suppressed ESCC growth in vitro. Overall design: Eca109 cells were treated with 1‰ DMSO or Evodiamine (1μM) for 24 h, and total RNAs were subjected t
MicroRNA expression profiles were sucessfully contructed in 63 patients with ICC and 9 normal intrahepatic bile ducts using a custom microarray containing probes for 1094 miRNAs and an outcome predict
Aneuploidy, a near ubiquitous genetic feature of tumors, is a context-dependent driver of cancer evolution, but the mechanistic basis of this role remains unclear. By inducing heterogeneous aneuploidy
We find significant evidence of the OVOL, AP1, STAT1, STAT3, and NFKB1 TFs having important roles in MET. We prioritize known gene/drug targets for follow-up in the clinic, and show that the AP1/MYC T
