Aguilera2017 - Model for IRF7 circuit

Model destription: The model describes the dynamics of murine IRF7 gene expression upon IFN stimulation. The present model comprises known key components and feedback mechanisms. The overall system describes the active IRF7 promoter (Pa) by the binding of IRF7 dimer and ISGF3 to the DNA binding sites ISRE and IRFE, respectively, the transcription and translation of IRF7, and its subsequent phosphorylation and dimerization. IRF7 protein binding to the IRFE binding site in the promoter results in the production of more IRF7 protein, constituting a positive feedback loop. Publication: A New Efficient Approach to Fit Stochastic Models on the Basis of High-throughput Experimental Data Using a Model of IRF7 Gene Expression as Case Study Authors Luis U. Aguilera, Christoph Zimmer and Ursula Kummer.