Targeted Delivery of Young Mitochondria Promotes Osteogenic Differentiation of Senescent Periodontal Stem Cells and Its Mechanisms

In this study, we demonstrate that mitochondrial transfer from young hPDLSCs to senescent hPDLSCs restores mitochondrial function and osteogenic differentiation capacity. Our results further indicate that mitochondrial transfer activates the cAMP/PKA pathway. Collectively, our findings provide direct evidence that mitochondrial transfer effectively promotes bone regeneration in hPDLSCs.