Mutations identified by whole genome sequencing on 4 <i>E. coli</i> isolates of patient 3.

aThe numbers between nucleotides correspond to the localisation of the mutation in the CFT073 genome according to MaGe [79] whereas the number between the amino acids corresponds to the amino acid numbering of the protein, when relevant. bThe variation is given for the protein itself or for proteins directly regulated by the encoded protein. Plus and minus signs indicate increased or decreased level of protein, respectively. Data are from the proteomic analysis (Table 3).