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资源简介：
通过对过表达 YAP 的脂肪间充质干细胞进行转录组测序，探讨 YAP 影响脂肪间充质干细胞成脂分化的分子机制。
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创建时间：
2025-03-02
相关数据集
RNA-seq on MCF10A-YAP5SA cells (overexpressed constrictively activated YAP in MCF10A cells) transduced with sgRNAs vectors targeting the TEAD4 binding motif within the identified enhancers
We performed a CRISPR-based functional genetic screen targeting TEAD4 binding motif located within the YAP-bound enhancers. The screen identified seven functional enhancers whose targeting resulted i
NIAID Data Ecosystem100
SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK–ERK1/2 signaling pathway
Obesity is a chronic metabolic disorder characterized by the accumulation of excess fat in the body. Preventing and controlling obesity by inhibiting the adipogenic differentiation of mesenchymal stem
Figshare2022-09-09 更新80
Induction of YAP5SA-GFP vs nGFP expression in FlipinTrex293 cells. Induction of YAP5SA-GFP vs nGFP expression in FlipinTrex293 cells
Dox-inducible YAP5SA-GFP/nGFP were treated with Doxycycline for 24 hours each and compared to non-treated controls Overall design: Cells were grown to confluence in Tet-free medium (using Tet-compatib
NIAID Data Ecosystem40
Additional file 6 of A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Additional file 6: Table S5. Proteomics data analysis of MCF10A-YAP5SA and MCF10A-TRAM2 cells.
Figshare2024-02-06 更新90
Caveolin-1 modulates mechanotransduction responses to substrate stiffness through actin-dependent control of YAP. Caveolin-1 modulates mechanotransduction responses to substrate stiffness through actin-dependent control of YAP
The transcriptional regulator YAP orchestrates important cell functions, determining tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, bu
NIAID Data Ecosystem50
