The formation and maintenance of granulomas is central to the host response to Mycobacterium tuberculosis (Mtb) infection. It is widely accepted that the lungs of patients with tuberculosis (TB) usual

NIAID Data Ecosystem30

scTCR-seq sequencing and analysis of fresh resected lung tissues from tuberculosis patients. scTCR-seq sequencing and analysis of fresh resected lung tissues from tuberculosis patients

结核病免疫病理学

单细胞T细胞受体分析

Tuberculosis-affected lungs with chronic inflammation harbor abundant immunosuppressive immune cells but the nature of such inflammation is unclear. Dysfunction in T cell exhaustion, while implicated

NIAID Data Ecosystem10

Mus musculus strain:C3HeB/FeJ Transcriptome or Gene expression. Mus musculus strain:C3HeB/FeJ

结核病免疫病理学

肉芽肿微环境调控

The regulatory networks involved in the development of hypoxic and necrotic granulomas following Mycobacterium tuberculosis infections remained elusive. The goal of the study was to determine the role

NIAID Data Ecosystem40

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.

结核病免疫病理学

蠕虫共感染免疫调节

We analyzed gene expression in CD4+ cells sorted from naïve or D30 Mycobacterium tuberculosis-infected mice and incubated in vitro in the presence or absence of Schistosoma egg antigen. We found gene

NIAID Data Ecosystem10

Vitamin D among patients of pulmonary and extra pulmonary tuberculosis

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