Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, S
Normal brain aging is marked by a cognitive decline, spurred by changes in cellular metabolism and homeostatic dysregulation, as well as modifications in synapses and neuronal connectivity. Astrocytes
Comparison of gene expression and ribosome profiles from Nothobranchius furzeri brain of 2 age groups. The RNA-seq and ART-seq data comprise 2 groups: 6 and 26 weeks. Jena Centre for Systems Biology o
A multimodal analysis of the macaque somatosensory cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quan
Aging is a major risk factor for late-onset Alzheimer’s disease (LOAD). How aging contributes to the development of LOAD remains elusive. In this study, we examined multiple large-scale transcriptomic