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Transcriptome analysis of TFAM-depleted HepG2 cells and HeLa cells

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NIAID Data Ecosystem2026-03-14 收录
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We conducted transcriptome analysis of TFAM-depleted HepG2 cells and HeLa cells as a mitochondrial stress model. We found that mitochondrial dysfunction upregulated unique secretory proteins such as amphiregulin (AREG) and thrombospondin 1 in hepatic cells. We depleted TFAM in HepG2 human hepatic cells or HeLa human cervix adenocarcinoma cells using two different siRNAs, and then carried out an expression microarray experiment.

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2022-09-29
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