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Loss of Trex1 in dendritic cells is sufficient to trigger systemic autoimmunity

ChEBI2016-08-01 更新2026-07-12 收录

自身免疫病机制

树突状细胞功能

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-77693 数据链接链接失效反馈

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资源简介：

Loss of Trex1 in dendritic cells is sufficient to trigger systemic autoimmunity

应用场景：

创建时间：

2016-08-01

肠道免疫细胞

树突状细胞功能

Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell population composed of distinct subsets

NIAID Data Ecosystem60

Total RNA-sequence, TRIM28 deficient mouse spleen dendritic cells

免疫系统基因

树突状细胞功能

TRIM28 is a nuclear protein that is crucial for gene silencing through heterochromatin formation and maintenance. A genetic loss of TRIM28 in mouse dendritic cells, a professional antigen presenting c

NIAID Data Ecosystem30

Prmt5 deficiency inhibits CD4+T cells migration through Klf2-S1pr1 and ameliorates EAE disease (scATAC-seq)

自身免疫病机制

细胞迁移

Protein arginine methyltransferase 5 (Prmt5) is the major type II methyltransferase catalyzing symmetric dimethylation, regulates cell development, homeostatic and disease processes. Prmt5 inhibition

NIAID Data Ecosystem20

Human monocyte-derived dendritic cells treated with U0126 or SB203580

细胞信号通路

树突状细胞功能

Human monocyte-derived dendritic cells treated with U0126 or SB203580

ChEBI2013-05-03 更新40

MoDCs grown with/without Etanercept TNF inhibitor

TNF抑制剂

树突状细胞功能

The process for making monocyte derived DCs (moDCs) has been previously described (46). All analysis was performed on “day 5” immature DCs. Etanercept 10mg/mL was added to experimental wells on days

NIAID Data Ecosystem30

Loss of Trex1 in dendritic cells is sufficient to trigger systemic autoimmunity

资源简介：

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