BackgroundGlycolysis dysfunction is an important pathogenesis of podocyte injury in diabetic kidney disease (DKD). Foot process fusion of podocytes and increased albuminuria are markers of early DKD.

NIAID Data Ecosystem30

GSH-deficiency promotes basal hyperinsulinemia in the insulin secreting cell line INS-1

胰岛素分泌机制

细胞代谢调控

This study sought to determine the impact of glutathione (GSH) synthesis on beta-cell function. To induce GSH deficiency, GCLC was inhibited in INS-1 cells using buthionine sulfoximine (BSO). The 24-h

NIAID Data Ecosystem10

Transcriptome sequencing of splenic CD4+ T cells from systemically hypoxic mice

低氧病理学

细胞代谢调控

Despite significant advances in understanding cellular responses to hypoxia and the biology of hypoxia-inducible factors (HIFs), the impact of systemic hypoxia on immune responses, particularly in CD4

NIAID Data Ecosystem30

Dgat1 detoxifies androgen receptor signaling to promote antitumor CD8+ T cell responses

肿瘤免疫治疗

细胞代谢调控

The role of fatty acid (FA) oxidation 31 in T cell responses has been extensively studied, but whether FA esterification to triacylglycerol (TAG) regulates T cell exhaustion is unknown. Dgat1 catalyze

NIAID Data Ecosystem10

glycans_pH Analysis Files

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