Bulk RNAseq of anti-PD1-induced cardiac dysfunction in C57BL/6J mice. Bulk RNAseq of anti-PD1-induced cardiac dysfunction in C57BL/6J mice

C57BL6/J mice were treated with anti-PD-1 for 2 or 4 weeks, or with isotype control antibody. In echocardiography, cardiac dysfunction was seen both after 2 and 4 weeks, with decreased ejection fraction and left ventricular dilation. Bulk RNA sequencing of the hearts after treatment was performed to identify the mechanisms of anti-PD-1-induced cardiac dysfunction.