BackgroundTopoisomerase II is critical for DNA replication, transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophy
Additional file 3. CellDesigner map of the circadian clock. This map is provided under the CellDesigner format (extended SBML) and can be visualized using CellDesigner
Tumor angiogenesis is regulated by pro- and anti-angiogenic factors. Anti-angiogenic agents target the interconnected network of angiogenic factors to inhibit neovascularization, which subsequently im
The formation and structure of the 5′–G[8–5]U–3′ intrastrand cross-link are studied using density functional theory and molecular dynamics simulations due to the potential role of this lesion in the a
