Profile of <i>Chlamydia</i> vaccine research: A bibliometric analysis

Vaccination is the most effective measure to prevent <i>Chlamydia</i> infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective <i>Chlamydia</i> vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding <i>Chlamydia</i> vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. <i>Vaccine</i> has published the most literature on <i>Chlamydia</i> vaccines. Only scholars from 39 countries/regions have been engaged in studying <i>Chlamydia</i> vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.

疫苗接种是预防衣原体（Chlamydia）感染最为有效的手段。然而截至目前，尚无任何一款疫苗能够通过严格的临床试验流程并获得临床应用的监管批准。学界始终致力于研发安全且有效的衣原体疫苗。为全面把握该领域的全球研究前沿与发展趋势，本研究开展了一项全面的文献计量分析。本研究从Web of Science核心合集数据库中筛选得到234篇与衣原体疫苗密切相关的学术文献，随后借助CiteSpace与VOSviewer软件提取其文献计量学信息。经计量分析后，本研究识别出该领域内的高影响力文献，包括高被引论文、强引用突现文献以及高共被引论文。期刊《疫苗》（Vaccine）刊载的衣原体疫苗相关文献数量最多。目前仅有来自39个国家/地区的学者参与衣原体疫苗相关研究。美国是该领域发文量最高且合作强度最大的国家。当前研究热点集中于保护性免疫与免疫病理反应。主要外膜蛋白（Major Outer Membrane Protein，MOMP）是最常用的疫苗靶标抗原。本研究阐明了该领域的文献研究现状，并揭示了新兴发展趋势，可为该领域研究者提供研究思路与后续研究的参考指引。

搜集汇总

背景与挑战

背景概述

该数据集是衣原体疫苗研究的文献计量分析，基于Web of Science Core Collection数据库中的234篇出版物，使用CiteSpace和VOSviewer软件进行计量分析，揭示了研究现状和趋势，如美国是最多产的国家，主要研究焦点为保护性免疫和免疫病理反应，主要外膜蛋白（MOMP）是常见靶点抗原。数据集发布于2025年，包含资助、分类和关键词等信息，适用于微生物学和免疫学领域的研究参考。