Epigenetic immunomodulation by association of guadecitabine with ipilimumab (NIBIT-M4 Phase Ib trial, NCT02608437) has been shown to be safe and tolerable in advanced melanoma and to have significant
In this study we investigated variation in responsiveness to anti-PD-1 using a model where we implanted the MC38 colorectal cancer cell line in genetically diverse host mice. To quantify differences i
BackgroundPyroptosis is a novel identified form of inflammatory cell death that is important in the development and progression of various diseases, including malignancies. However, the relationship b
