Tumor biology is determined not only by immortal cancer cells but also its tumor microenvironment consisted of non-cancerous cells and extracellular matrix, together they dictate pathogenesis and resp
MICAgen mice were treated sc with 100 µg MCA. Around 100 days later, mice bearing fibrosarcomas were randomized to five groups and treated once with vehicle or 0.5 or 2 mg/kg MICAB1 PDB2G-ADCs or IC-P
We previously generated genetically engineered mouse (GEM) models based on perturbation of Tp53, Rb with or without Brca1 or Brca2 that develop serous epithelial ovarian cancer (SEOC) closely resembli
The lack of predictive preclinical models is a fundamental barrier to translating knowledge about the molecular pathogenesis of cancer into improved therapies. Insertional mutagenesis (IM) in mice is
