Major cardiovascular events (Panel A) and major cerebrovascular events (Panel B): crude and adjusted Cox models.

Model 1 is adjusted by smoking status, alcohol consumption, physical activity, Italian Mediterranean Index, energy intake, and body mass index. Model 2 is adjusted by baseline hypertension, baseline hypercholesterolemia, and prevalent diabetes. Model 3 is adjusted as in Model 1+ Model 2. All models are adjusted by age and sex and stratified by center.