Here, we took advantage of well-defined mouse models for β-amyloidosis (APPPS1) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-ta
1T-test or Wilcoxon rank sum test. CH-NAT = cognitively healthy with normal CSF amyloid/Tau ratio. CH-PAT = cognitively healthy with pathological CSF amyloid/Tau ratio.
High-resolution mass spectrometry (HRMS)-based untargeted metabolomics strategies have emerged as an effective tool for discovering biomarkers of Alzheimer’s disease (AD). There are various HRMS-based
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. Despite extensive research, the complex molecular mechanisms underlying AD remain inco
