Additional file 3: Supplementary Excel File 1a. DEPs from 5xFAD versus wild-type tissue comparisons in hippocampus and cortex; DEPs were defined using the “pairwise model”; Supplementary Excel File 1b
Table S2. iTRAQ quantified human brain proteome of AD individuals and their age-matched control with more than 2 peptides. The data is combined search of three biological replicates. (XLSX 1485 kb)
The two hallmarks of Alzheimer’s disease (AD) are A-amyloid- (A) plaques and neurofibrillary tangles marked by phosphorylated tau. There is compelling evidence that aggregating A drives tau accumulati
Table S4. Gene ontology (GO) term enrichment for differentially expressed proteins in AD. The enriched GO terms with associated P values (Benjamini-Hochberg FDR corrected) for biological processes, ce
Additional file 4: Table S2. List of proteins identified in label-free MS analysis of amyloid fibrils isolated from mouse cortices. Proteins identified with a higher abundance in purified fibrils (N =