Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice

This dataset includes the data from a study investigating the interactions of polychlorinated biphenyls (PCBs) and their metabolites with the brain and liver transcriptome of female mice. Female C57BL/6J mice (> 6 weeks) were orally exposed for 7 weeks to a human-relevant PCB mixture (MARBLES mix) at 0, 0.1, 1, and 6 mg/kg body weight/day. PCB and OH-PCB levels were quantified in the brain, liver, and serum; RNA sequencing was performed in the striatum, prefrontal cortex, and liver, and metabolomic analyses were performed in the striatum. Network analysis was performed to characterize interactions between individual PCBs and their metabolites and specific differentially expressed genes (DEGs).