Extended Data Fig. 6b

Raji B-cell lymphoma cells expressing the MICA*001 or MICA*008 allele with low and medium level were injected i.p. into NOD-SCID immunodeficient mice simultaneously treated once with 0.5 mg/kg of body weight of MICAB1-Fc-engineered mAb or BAMO3 mAb or isotype control mAb. Tumor cell counts in peritoneal cavity lavage 24 hours later are shown. <i>n</i>=8 per group. Kruskal-Wallis test. <b>c</b>, B16-F10 MICA*001 were engrafted s.c. in MICAgen mice. Five days later, mice bearing tumors were randomized into two groups (<i>n</i>=10/group) and treated weekly for three weeks with 10 mg/kg of either MICAB1-mIgG2a or isotype control mAb. Tumor volumes per mouse over time are shown