IHH gene transcription is stimulated by RUNX2

Based on studies in mice, binding of RUNX2, presumably in complex with CBFB, to evolutionarily conserved RUNX2 response elements in the promoter of the IHH gene stimulates IHH transcription. The IHH gene encodes Indian hedgehog, which controls limb growth by regulating chondrocyte proliferation and maturation (Yoshida et al. 2004).基于对小鼠的研究，RUNX2与CBFB形成的复合物结合至IHH基因启动子中的进化保守的RUNX2反应元件，可刺激IHH基因的转录。IHH基因编码印度刺猬蛋白，通过调节软骨细胞的增殖和成熟来控制肢体生长（Yoshida等，2004年）。