Portal Hypertension Induced Changes in Splenic microRNA Expression

Splenomegaly is caused by several pathological conditions, including portal hypertension, which is most frequently caused by chronic liver disease (e.g., liver cirrhosis). The detailed mechanisms through which portal pressure induces splenomegaly and the precise pathophysiological conditions in portal hypertension-induced splenomegaly remain to be fully elucidated. We used microarrays to identify the differential microRNA expression underlying the portal hypertension-induced splenomegaly.脾大（Splenomegaly）可由多种病理状态引发，其中门静脉高压是最常见的诱因，而门静脉高压多由慢性肝病（如肝硬化）所致。门静脉高压诱发脾大的具体机制，以及门静脉高压性脾大的确切病理生理状态，目前仍有待全面阐明。本研究采用微阵列（microarrays）技术，筛选鉴定出与门静脉高压诱导的脾大相关的差异表达微小RNA（microRNA）。