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Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming

NIAID Data Ecosystem2026-05-02 收录

心脏细胞重编程

细胞衰老调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267452 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-08-22

心脏细胞重编程

单细胞转录组学

Background: Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged as one of the promising strategies to remuscularize the injured myocardium. Yet, it is still insufficient to gen

NIAID Data Ecosystem40

Whole transcriptional analysis of induced cardiomyocytes from MICFs

心脏细胞重编程

转录组分析

We report that Sall4 and Myocd empower direct cardiac reprogramming from adult cardiac fibroblasts after myocardial infarction (MICFs). To examine the gene expression of induced cardiomyocytes (iCMs)

NIAID Data Ecosystem20

Dataset for: Regulation of cellular senescence via the FOXO4-p53 axis

细胞衰老调控

衰老相关疾病靶点

Forkhead box O (FOXO) and p53 proteins are transcription factors that regulate diverse signalling pathways to control cell cycle, apoptosis and metabolism. In the last decade both FOXO and p53 have be

Figshare2018-05-15 更新10

Activation of endogenous genes by CRISPRa enables conversion of mouse fibroblasts into cardiac progenitor cells

心脏细胞重编程

CRISPRa基因激活

In this study, we determine whether direct activation of endogenous loci by targeting the genomic DNA (using a CRISPRa system) can fulfill reprogramming of fibroblasts into cardiac progenitors. Core p

NIAID Data Ecosystem30

Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFV600E-induced Cellular Senescence in Human Melanocytes

黑色素瘤发生机制

细胞衰老调控

Melanoma arises from transformation of melanocytes in the basal layer of the epidermis where they are surrounded by keratinocytes, with which they interact through cell contact and paracrine communica

NIAID Data Ecosystem20

Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming

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