The transcriptome of pulmonary arterial endothelial cells from healthy lungs and from lungs of patients with idiopathic pulmonary arterial hypertension have been analyzed and specific differences in d

NIAID Data Ecosystem30

Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS [terminally differentiated iPSC-derived astrocytes]. Homo sapiens

ALS病理机制

iPSC疾病模型

Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remai

NIAID Data Ecosystem20

File S1 - The Disease-Specific Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Two Long QT Syndrome Type 3 Patients

iPSC疾病模型

心脏电生理学

The following files are included in File S1: Figure S1, Schematic of voltage-gated sodium channel structure and location of mutations described in this study. Figure S2, ECG analysis of the two LQTS-

NIAID Data Ecosystem60

Pluripotent stem cell models of Blau syndrome reveal an IFN- -dependent inflammatory response in macrophages. Homo sapiens

Blau综合征

iPSC疾病模型

Background: Blau syndrome, or early-onset sarcoidosis, is a juvenile-onset systemic granulomatosis associated with a mutation in Nucleotide-binding oligomerization domain 2 (NOD2). The underlying mech

NIAID Data Ecosystem20

Dissecting the contributions of cooperating cancer gene mutations to phenotype and drug susceptibility with patient-derived iPSCs

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