PRMT5 Bound to Compound 8 and MTA

PRMT5 Bound to Compound 8 and MTA Descriptor: 4-amino-1-methyl-N-(2-oxopiperidin-1-yl)-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}-1H-pyrazolo[4,3-c]quinoline-8-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... Authors: Ferrao, R. Deposit date: 2025-08-06 Release date: 2026-01-07 Last modified: 2026-01-14 Method: X-RAY DIFFRACTION (3.04 Å) Cite: Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect. J.Med.Chem., 69, 2026