Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease. Mus musculus
收藏NIAID Data Ecosystem2026-03-08 收录
官方服务：
资源简介：
Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. Overall design: We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function.
创建时间：
2014-08-23
