The microenvironment exerts a profound control on tumor initiation in many tissues. In brain tumors, this process is under studied, in particular how stromal signals exert effects on cancer signaling
Spatial multi-omics reveals the niche-specific distribution and vulnerablity of stem-like cells in pediatric and adult malignant gliomasrelated seurat object or m6a relate rds/table or ONT PSI matrix
Glioblastoma (GBM) is the most prevalent and aggressive malignant primary brain tumor. GBM proximal to the lateral ventricles (LVs) is more aggressive, potentially due to subventricular zone (SVZ) con
The interplay between glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) promotes progression of glioblastoma multiforme (GBM). However, the detailed molecular mechanisms underlyin
Microglia are a major cellular component of gliomas, and abundant in the centre of the tumour and at the infiltrative margins. While glioma is a notoriously infiltrative disease, the dynamics of micro
