Administration of the noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist phencyclidine (PCP) to rodents is widely used as preclinical model for schizophrenia. Most studies on this model em
Population-based studies show cannabis use doubles the risk of developing schizophrenia especially when use occurs in early adolescence (prior to age 15). However, the cause-and-effect mechanisms are
This study investigates the role of TrkB in PV and SST interneurons and explores the validity of an interneuron-specific TrkB knockout mouse model. Mice with reduced TrkB expression in either PV-INs o
Contemporary rodent models for bipolar disorders split the bipolar spectrum into complimentary behavioral endophenotypes representing mania and depression. Widely accepted mania models typically utili
