Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

To characterize female aged Efemp1 R345W knock-in (Efemp1ki/ki) mice, a model for Doyne honeycomb retinal dystrophy/malattia leventinese by bulk RNA sequencing We performed differential expression and gene set enrichment analysis analysis using data obtained from RNA-seq of the neural retina and posterior eyecups (whole eye without lens and retina) from 3- to 17-month-old Efemp1+/+ and Efemp1ki/ki mice Gene expression profiling analysis of RNA-seq data of of the neural retina and posterior eyecups (whole eye without lens and retina) from 3- to 17-month-old Efemp1+/+ and Efemp1ki/ki mice本研究针对作为多因氏蜂窝状视网膜营养不良/莱文廷塞病（Doyne honeycomb retinal dystrophy/malattia leventinese）模型的Efemp1 R345W纯合敲入（Efemp1ki/ki）雌性老龄小鼠，采用批量RNA测序（bulk RNA sequencing）技术开展表征分析。我们采集了3至17月龄的Efemp1野生型（Efemp1+/+）与Efemp1ki/ki小鼠的神经视网膜及后眼杯（即去除晶状体与视网膜的完整眼球组织）的RNA测序数据，基于此完成差异表达分析与基因集富集分析（gene set enrichment analysis），并针对上述样本的RNA测序数据开展基因表达谱分析。