Meta-Analysis of the Association Between <i>VEGF</i>-2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy

to investigate the association between vascular endothelial growth factor (<i>VEGF)</i>-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis. According to the search strategy, Four databases were retrieved to identify the literature on the relationship between <i>VEGF</i> polymorphism and the risk of T2DR from inception to July 2024. Stata 15.0 was used for data processing. Ten articles were involved in this review, covering 1390 cases and 1306 controls. The pooled results exhibited that the risk of T2DR was associated with <i>VEGF</i>-2578C/A polymorphism under the allele model (A/C: OR= 1.33, 95%CI: 1.04–1.72, <i>p</i> = 0.025) and dominant models (AA+CA/CC: OR= 1.38, 95%CI: 1.00–1.91, <i>p</i> = 0.047). However, in recessive, homozygous, and heterozygous models, no significant difference was observed (all <i>p</i> &gt; 0.05). The <i>VEGF</i>-2578C/A polymorphism is associated with susceptibility to T2DR. In particular, allele A and genotype AA+CA at the <i>VEGF</i>-2578C/A locus were significantly associated with an increased risk of T2DR.

本研究旨在通过荟萃分析（meta-analysis）探究血管内皮生长因子（vascular endothelial growth factor, VEGF）-2578C/A基因多态性与2型糖尿病视网膜病变（type 2 diabetic retinopathy, T2DR）易感性的关联。按照既定检索策略，本研究检索4个数据库，筛选建库至2024年7月期间发表的、关于VEGF基因多态性与T2DR发病风险相关性的文献。采用Stata 15.0软件开展数据处理。本综述共纳入10篇文献，涉及1390例病例组与1306例对照组。合并分析结果显示，在等位基因模型（A/C：比值比（odds ratio, OR）=1.33，95%置信区间（95% confidence interval, 95%CI）：1.04~1.72，p=0.025）与显性遗传模型（AA+CA/CC：OR=1.38，95%CI：1.00~1.91，p=0.047）下，T2DR发病风险与VEGF-2578C/A基因多态性存在显著关联。然而，在隐性遗传模型、纯合子模型与杂合子模型中，未观察到统计学显著性差异（所有p>0.05）。综上，VEGF-2578C/A基因多态性与T2DR易感性相关；其中，该位点的等位基因A及基因型AA+CA与T2DR发病风险升高显著相关。