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Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells

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NIAID Data Ecosystem2026-03-11 收录
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The human pluripotent stem cells cultured on Low-adhesion substrates formed two morphologically different subtypes (Monolayer and Domed). The dome-like cells showed higher proliferation capacity and KLF4/5 expression than the monolayer cells. A serum response factor based regulatory double loop was proposed to explain how cell-matrix adhesion mediates the interaction between cell morphology and pluripotency genes Compare the two type cells with RNA-seq to investigate the different expression

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2019-05-21
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