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An in-vivo screen of noncoding elements reveals that Daedalus is a gatekeeper of a novel Ikaros-dependent checkpoint during haematopoiesis

NIAID Data Ecosystem2026-03-12 收录

造血干细胞调控

非编码基因功能

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE153879 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2021-03-24

基因组调控

非编码基因功能

Transversions (Tv's) are more likely to alter the amino acid sequence of proteins than transitions (Ts's), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Wh

NIAID Data Ecosystem60

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homesotasis. Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homesotasis

造血干细胞调控

分子受体功能研究

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem20

Genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment

造血干细胞调控

转录因子功能研究

Self-renewing multipotent hematopoietic stem cells (HSCs) are a rare but important cell population which can reconstitute the entire blood and immune system following transplantation. Due to their rar

NIAID Data Ecosystem20

Differential Expression of Novel Potential Regulators in Hematopoietic Stem Cells.. Mus musculus

造血干细胞调控

基因表达谱分析

Pairwise comparisons of purified mouse LT-HSC, ST-HSC and MPP. The hematopoietic system is an invaluable model both for understanding basic developmental biology and for developing clinically relevant

NIAID Data Ecosystem50

Non-coding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability [bulk RNA-seq]

染色体三维结构

非编码基因功能

In this study, we performed network analysis on Hi-C data and identified a group of non-coding regions forming many 3D contacts (referred to as hubs). Through a high-throughput CRISPR-Cas9 library scr

NIAID Data Ecosystem20

An in-vivo screen of noncoding elements reveals that Daedalus is a gatekeeper of a novel Ikaros-dependent checkpoint during haematopoiesis

资源简介：

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