The highly conserved histone chaperone FACT (Facilitates Chromatin Transcription) is thought to contribute to the disassembly and reassembly of nucleosomes in the wake of RNA Polymerase II (Pol II) pa

NIAID Data Ecosystem20

Structural and mechanistic basis of sigma-dependent transcriptional pausing

转录暂停机制

sigma因子调控

Using site-specific protein-DNA photocrosslinking, high-throughput sequencing, and cryo-EM structure determination, we show directly that sigma-dependent pausing involves DNA scrunching, we define a c

NIAID Data Ecosystem20

Escherichia coli Transcriptome or Gene expression. Escherichia coli

大肠杆菌基因表达与表型

结直肠癌遗传关联

colon cancer has some relevance with this bacteria

NIAID Data Ecosystem50

Promoter-proximal pausing mediated by the exon junction complex regulates splicing [HA ChIP]

转录暂停机制

RNA剪接调控

Promoter-proximal pausing of RNA polymerase II (Pol II) is a widespread transcriptional regulatory step across metazoans. Here we find that the nuclear exon junction complex (pre-EJC) is a critical an

NIAID Data Ecosystem20

Transcription Pausing in E. coli (Part 2). Escherichia coli str. K-12 substr. MG1655

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