Hypoxia activates AMPK and drives NLRP3-mediated pyroptosis in periodontitis. Hypoxia activates AMPK and drives NLRP3-mediated pyroptosis in periodontitis

Hypoxia has a significant impact on periodontal homeostasis and is a contributing factor to periodontal pathogenicity. This study aimed to investigate the role and mechanism of hypoxia in periodontitis. Overall design: We performed RNA-seq on human acute monocytic leukemia（THP-1）cells.