Blood brain barrier (BBB) permeability of injectable (S)-roscovitine.
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(S)-roscovitine permeability to the BBB solubilized in 4% HPbCD was examined after IV administration of the compound to healthy adult rats. (S)-roscovitine was administered at 2 doses (20 and 30 mg/kg) to the animals (n = 2 rats/dose) and (S)-roscovitine level was determined in the brain and plasma 15 min later. Approximately 15% of the IV injected (S)-roscovitine was able to cross the BBB in healthy adult rats.
创建时间：
2010-08-12
