S1 File - Establishment of an in vivo analytical method for detecting total anti-UFH activity and pharmacokinetic study in PS and R15 in rats

S1 Table. Standard curve of PS in blank plasma. S2 Table. Standard curve of R15 in blank plasma. S3 Table. The stability of PS plasma sample placed in room temperature (25°C) for 30 min (n = 6). S4 Table. The stability of PS plasma sample freeze-thaw three cycles in −20°C (n = 6). S5 Table. The stability of stock solution of PS for 1 week (n = 6). S6 Table. The stability of R15 plasma sample placed in room temperature (25°C) for 30 min (n = 6). S7 Table. The stability of R15 plasma sample freeze-thaw three cycles in −20°C (n = 6). S8 Table. The stability of stock solution of R15 for 1 week (n = 6). S9 Table. Dilution effects of varying concentrations of plasma samples of PS diluted 2-fold, 5-fold, 10-fold, 20-fold (n = 5). S10 Table. Dilution effects of varying concentrations of plasma samples of R15 diluted 2-fold or 100-fold (n = 5). S11 Table. Pharmacokinetic parameters of intravenous infusion administration with PS (300 U/kg) to individual Wistar rats (n = 6). S11 Table. Pharmacokinetic parameters of intravenous infusion administration with PS (300 U/kg) to individual Wistar rats (n = 6). S12 Table. The plasma concentration of PS after intravenous infusion administration with PS (300 U/kg) to individual Wistar rats. ND: Not determined. S13 Table. Pharmacokinetic parameters of intravenous infusion administration with R15 (2700 U/kg) to individual Wistar rats (n = 8). S14 Table. Pharmacokinetic parameters of intravenous infusion administration with R15 (900 U/kg) to individual Wistar rats (n = 8). S15 Table. Pharmacokinetic parameters of intravenous infusion administration with R15 (300 U/kg) to individual Wistar rats (n = 8). S16 Table. The plasma concentration of R15 after intravenous infusion administration with R15 (300 U/kg) to individual Wistar rats. ND: Not determined. S17 Table. The plasma concentration of R15 after intravenous infusion administration with R15 (900 U/kg) to individual Wistar rats. ND: Not determined. S18 Table. The plasma concentration of R15 after intravenous infusion administration with R15 (2700 U/kg) to individual Wistar rats. ND: Not determined. (ZIP)