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A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

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NIAID Data Ecosystem2026-03-11 收录
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Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level. It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modifications(H3K4me3, H3K27me3, H3K9me3 and 5-methylcytosine).

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2019-05-15
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