Upregulated genes and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways.

Using the Goeman's global test method the degree of distinction between myeloma cell samples (MM) and normal bone marrow plasma cell (BMPC) samples was investigated. The significance of p-level indicates the degree of difference between then BMPC and the MM samples. Glycan pathways were ordered according to the general families of macromolecular glycan structures, i.e. GPI-anchored glycoproteins, N- and O-glycosylated glycoproteins, glycosphingolipids (GSL) and proteoglycans (heparan sulfate (GAG-HS) glycosaminoglycans (GAG); chondroitin sulfate (GAG-CS) and keratin sulfate (GAG-KS). Most significant changes in the MM glycome were found in the GPI- and in the HS synthesis and were highlighted.