Endometrial cancer (EC) is the most frequent gynecological cancer. Tumor dissemination affecting ∼20% of EC patients is characterized at the primary carcinoma by epithelial-to-mesenchymal transition (
WNT2 is important for placenta vascularization and acts as a pro-angiogenic factor for liver and other endothelial cells (ECs). WNT2 induction has been shown in many carcinomas and is associated with
PTK2B is highly expressed in glioma DBTRG-05MG cells harboring BRAFV600E mutation, and its knockdown induces severe cell death. To explore the anti-tumor mechanism of targeting PTK2B and elucidate its