官方服务：
资源简介：
primary ALL cells from bone marrow aspirates taken two days after in vivo treatment with low-dose methotrexate and mercaptopurine Keywords: other
应用场景：
创建时间：
2018-12-13
相关数据集
Toosendanin Suppresses Acute Myeloid Leukemia by Targeting DDX5/c-Myc Axis to inhibit Protein Synthesis
The treatment of acute myeloid leukemia (AML) continues to be challenged by relapse and resistance, necessitating the development of novel therapeutic strategies. Toosendanin (TSN), a natural product
NIAID Data Ecosystem70
Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells
Tumor protein p53 is a key regulator of several cellular pathways, including DNA repair, cell cycle and angiogenesis. Kevetrin exhibits p53-dependent as well as independent activity in solid tumors, w
NIAID Data Ecosystem20
Discovery of 1‑(4-(4-Amino-3-(4-(2-morpholinoethoxy)phenyl)‑1 H ‑pyrazolo[3,4‑ d ]pyrimidin-1-yl)phenyl)-3-(5‑( tert -butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML
FLT3-ITD mutant has been observed in about 30% of AML patients and extensively studied as a drug discovery target. On the basis of our previous study that ibrutinib (9) exhibited selective and moderat
NIAID Data Ecosystem20
Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia
Nowadays, the simultaneous inhibition of two or more pathways plays an increasingly important role in cancer treatment due to the complex and diverse pathogenesis of cancer, and the combination of the
NIAID Data Ecosystem50
The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway. Homo sapiens
Acute myeloid leukemia is a heterogeneous disease with regard to the underlying genetic and molecular pathophysiology. Non-steroidal anti-inflammatory drugs (NSAIDs) exert significant anti-proliferati
NIAID Data Ecosystem20
