Morphogenesis and regeneration share a conserved core transition cell state program that control lung epithelial cell fate

We isolated and identified a population of Icam1/Nkx2-1 epithelial progenitors harboring a transitional state program remarkably conserved in humans and mice during lung morphogenesis and regeneration Epcam+ or Epcam+Icam1+ cells from E14.5 mouse embryonic lungs are isolated and proceeded to single cell sequencing本研究分离并鉴定了一群细胞间黏附分子1（Icam1）/同源盒基因Nkx2-1阳性的上皮祖细胞群，该细胞群携带一套在人类与小鼠的肺形态发生及再生过程中高度保守的过渡态程序；研究人员从胚胎发育第14.5天（E14.5）的小鼠胚胎肺中分离得到上皮细胞黏附分子（Epcam）阳性或上皮细胞黏附分子（Epcam）阳性/细胞间黏附分子1（Icam1）阳性细胞，并对其开展了单细胞测序。