Supplementary Material for: ECTOPIC CUSHING’S SYNDROME SECONDARY TO ACINIC CELL CARCINOMA OF THE PAROTID GLAND: A CASE-REPORT

Ectopic secretion of adrenocorticotropic hormone (ACTH) by non-pituitary tumours is a rare cause of Cushing’s syndrome (CS). We present a case report of a patient with a rare high-grade transformation of an acinic cell carcinoma (ACC) of the parotid gland, who developed CS as a result of ectopic secretion of ACTH by the tumour. The hypercortisolism was successfully treated with metyrapone, and the ACC was treated with local radiotherapy and a combined six cycles of gemcitabine and cisplatin, with partial response of the tumour. A multidisciplinary approach and combined medical treatment with radiotherapy were essential for disease control and CS management. ACC should be considered in the differential diagnosis of ectopic CS.