Argonaute proteins are programmable nucleases that are found in both eukaryotes and prokaryotes and provide defense against invading genetic elements. Although some prokaryotic Argonautes (pAgos) were
The widespread use of the Cas12a (formerly Cpf1) nuclease for gene editing, especially in clinical applications, is hindered by insufficient activity and specificity. Currently reported Cpf1 variants
Crystal structure of xCas9 in complex with sgRNA and DNA (TGC PAM) Descriptor: CRISPR-associated endonuclease Cas9/Csn1, non-targeted DNA, sgRNA, ... Authors: Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan
