Inhibitor of MDM2-p53 Interaction
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Inhibitor of MDM2-p53 Interaction Descriptor: (3~{R})-3-(4-chlorophenyl)-2-[(4-ethynylphenyl)methyl]-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-6-(2-oxidanylpropan-2-yl)isoindol-1-one, 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2 Authors: Williams, P.A. Deposit date: 2021-01-20 Release date: 2021-04-07 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
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2021-01-20
