To explore the role played by senescent cells in mice models of pulmonary hypertension we exposed young C57BL6/j mice to 8 days hypoxia or normoxia and treated with senolytic drug ABT-263 (50mg/kg/day
Abbreviations: ERA = Endothelin receptor antagonists. PDE-5 = Phosphodiesterase Type 5 inhibitor. CCB = Calcium channel blocker. PGI2 = prostacyclin. All medications are taken in the usual dosing sche
Increased arginase 2 protein expression is associated with endothelial dysfunction and pulmonary hypertension, likely by impairing NO production secondary to substrate availability. Hypoxia induces ar
