Raw Data Sheet.xlsx

<b>Pancreatic ductal adenocarcinoma (PDAC) presents at advanced stages and is refractory to most treatment modalities. Wnt signaling activation plays a critical role in proliferation and chemotherapeutic resistance. </b><b>Minimal media conditions, growth factor dependency, and Wnt dependency were determined via Wnt inhibition for seven patient derived organoids (PDOs) derived from pancreatic tumor organoid libraries (PTOL). </b><b>Organoids demonstrating response </b><b><i>in vitro</i></b><b> were assessed </b><b><i>in vivo</i></b><b> using patient-derived xenografts. </b><b>Wnt (in)dependent gene signatures were identified for each organoid.</b>