Optimization of second-line therapy with aflibercept, irinotecan (day1 or day 1,3), 5fluorouracile and folinic acid in patients with metastatic colorectal cancer. A randomized Phase III study.
External Beam Radiation Therapy (EBRT) is predominantly administered using Conventionally Fractionated Radiotherapy (CFRT), that is 2 Gy per fraction. However, Moderately Hypofractionated Radiotherapy
A decision model is developed to compute several optimal treatment packages under considerations of treatment compatibility and personal constraints. The mathematical formulation is posed as a minimax
